Diabetic retinopathy


diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries None


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Check pre-conditions, main-only, mode, ICD version None


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Check minimum number of events None


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Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 12242 5972 6270
Unadjusted prevalence (%) 3.97 3.44 4.64
Mean age at first event (years) 57.23 56.25 58.17


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.03 2.43 [1.97, 3.00] 8.8e-17 1626
15 years 0.01 1.55 [1.28, 1.88] 8.3e-6 827
5 years 0.00 2.96 [2.56, 3.44] 4.9e-47 509
1 year 0.00 3.35 [2.68, 4.20] 6.3e-26 115

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: DM_RETINOPATHY – Diabetic retinopathy
GWS hits: 17

Survival analyses between endpoints


before Diabetic retinopathy
after Diabetic retinopathy

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Drugs most likely to be purchased after Diabetic retinopathy