Proliferative diabetic retinopathy

DM_RETINA_PROLIF

proliferative diabetic retinopathy: Later stage of diabetic retinopathy, characterized by neovascularisation of the retina

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H36.03*

Hospital discharge: ICD-9 3620B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H36.03*

Cause of death: ICD-9 3620B

Cause of death: ICD-8 $!$

Operations: NOMESCO codes ^CKC10|^CKC15|^CKC12|^CKC50

7110

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7110

Check minimum number of events None

7110

Include endpoints

DM_RETINA_PROLIF_NOS_ET_OPER

7573

DM_RETINA_PROLIF

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Proliferative diabetic retinopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	7349	3548	3801
Unadjusted prevalence (%)	2.38	2.04	2.82
Mean age at first event (years)	55.07	54.24	55.85

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.86 [2.29, 3.57]	2.0e-20	889
15 years	0.01	1.87 [1.50, 2.32]	1.7e-8	462
5 years	0.00	3.16 [2.57, 3.88]	3.8e-28	256
1 year	0.00	3.46 [2.53, 4.74]	8.3e-15	55

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_RETINA_PROLIF – Proliferative diabetic retinopathy
GWS hits: 16

Survival analyses between endpoints

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Plot

before Proliferative diabetic retinopathy
after Proliferative diabetic retinopathy

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Table

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Drugs most likely to be purchased after Proliferative diabetic retinopathy

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