Proliferative diabetic retinopathy

DM_RETINA_PROLIF

proliferative diabetic retinopathy: Later stage of diabetic retinopathy, characterized by neovascularisation of the retina

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 H36.03*
Hospital discharge: ICD-9 3620B
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H36.03*
Cause of death: ICD-9 3620B
Cause of death: ICD-8 $!$
Operations: NOMESCO codes ^CKC10|^CKC15|^CKC12|^CKC50

7110

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7110

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Check minimum number of events None

7110

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Include endpoints

7573

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DM_RETINA_PROLIF

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

List of similar endpoints to Proliferative diabetic retinopathy based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Broader endpoints:

Venn diagram with a set fully inside an highlighted set Narrower endpoints:

Show all endpoint correlations

Summary Statistics

Key figures

All Female Male
Number of individuals 7349 3548 3801
Unadjusted prevalence (%) 2.38 2.04 2.82
Mean age at first event (years) 55.07 54.24 55.85

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.04 2.86 [2.29, 3.57] 2.0e-20 889
15 years 0.01 1.87 [1.50, 2.32] 1.7e-8 462
5 years 0.00 3.16 [2.57, 3.88] 3.8e-28 256
1 year 0.00 3.46 [2.53, 4.74] 8.3e-15 55

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: DM_RETINA_PROLIF – Proliferative diabetic retinopathy
GWS hits: 16

Survival analyses between endpoints

Plot

before Proliferative diabetic retinopathy
after Proliferative diabetic retinopathy

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Drugs most likely to be purchased after Proliferative diabetic retinopathy