Proliferative diabetic retinopathy

H7_RETINOPATHYDIAB_PROLIF

proliferative diabetic retinopathy: Later stage of diabetic retinopathy, characterized by neovascularisation of the retina

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H36.03*

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H36.03*

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

2074

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2074

Check minimum number of events None

2074

Include endpoints None

2074

H7_RETINOPATHYDIAB_PROLIF

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Proliferative diabetic retinopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2025	896	1129
Unadjusted prevalence (%)	0.66	0.52	0.84
Mean age at first event (years)	46.69	44.64	48.32

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	5.73 [3.21, 10.23]	3.7e-9	351
15 years	0.02	3.81 [2.40, 6.04]	1.2e-8	183
5 years	0.01	7.21 [5.16, 10.08]	6.7e-31	113
1 year	0.00	5.70 [3.34, 9.74]	1.9e-10	18

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETINOPATHYDIAB_PROLIF – Proliferative diabetic retinopathy
GWS hits: 11

Survival analyses between endpoints

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Plot

before Proliferative diabetic retinopathy
after Proliferative diabetic retinopathy

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Table

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Drugs most likely to be purchased after Proliferative diabetic retinopathy

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