Diabetic retinopathy

H7_RETINOPATHYDIAB

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H36.00*, H36.01*, H36.02*, H36.03*, H36.04*, H36.05*, H36.09*, H36.09*E10.3, H36.09*E11.3

Hospital discharge: ICD-9 3620

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H36.00*, H36.01*, H36.02*, H36.03*, H36.04*, H36.05*, H36.09*, H36.09*E10.3, H36.09*E11.3

Cause of death: ICD-9 3620

Cause of death: ICD-8 $!$

5631

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

5605

Check minimum number of events None

5605

Include endpoints

H7_RETINOPATHYDIAB_BKG

H7_MACULOPATHYDIAB

H7_RETINOPATHYDIAB_BKG_SEVERE

H7_RETINOPATHYDIAB_PROLIF

H7_RETINOPATHYDIAB_ADVANC

H7_RETINOPATHYDIAB_CONSEQ

H7_RETINOPATHYDIAB_NAS

5605

H7_RETINOPATHYDIAB

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diabetic retinopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	5443	2444	2999
Unadjusted prevalence (%)	1.76	1.41	2.22
Mean age at first event (years)	49.18	46.95	50.99

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.92 [3.00, 5.12]	1.7e-23	977
15 years	0.02	2.62 [2.10, 3.28]	1.5e-17	511
5 years	0.00	4.08 [3.32, 5.00]	2.4e-41	281
1 year	0.00	4.53 [3.35, 6.11]	5.1e-23	61

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETINOPATHYDIAB – Diabetic retinopathy
GWS hits: 13

Survival analyses between endpoints

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Plot

before Diabetic retinopathy
after Diabetic retinopathy

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Table

Loading survival analyses table

Drugs most likely to be purchased after Diabetic retinopathy

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