Severe diabetic background retinopathy

H7_RETINOPATHYDIAB_BKG_SEVERE

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H36.02*

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H36.02*

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

696

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

696

Check minimum number of events None

696

Include endpoints None

696

H7_RETINOPATHYDIAB_BKG_SEVERE

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Severe diabetic background retinopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Severe non-proliferative background diabetic retinopathy

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	672	277	395
Unadjusted prevalence (%)	0.22	0.16	0.29
Mean age at first event (years)	46.65	44.49	48.17

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.11	8.57 [5.17, 14.22]	8.4e-17	74
15 years	0.03	4.22 [2.47, 7.21]	1.3e-7	34
5 years	0.01	8.53 [4.77, 15.23]	4.4e-13	30
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETINOPATHYDIAB_BKG_SEVERE – Severe diabetic background retinopathy
GWS hits: 2

Survival analyses between endpoints

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Plot

before Severe diabetic background retinopathy
after Severe diabetic background retinopathy

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Table

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Drugs most likely to be purchased after Severe diabetic background retinopathy

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