Severe diabetic background retinopathy

H7_RETINOPATHYDIAB_BKG_SEVERE

eye disease: A non-neoplastic or neoplastic disorder that affects the eye. Representative examples include conjunctivitis, glaucoma, cataract, conjunctival squamous cell carcinoma, uveal melanoma, and retinoblastoma. [NCIt:C26767]

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 H36.02*
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 H36.02*
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$

696

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

696

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Check minimum number of events None

696

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Include endpoints None

696

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H7_RETINOPATHYDIAB_BKG_SEVERE

Extra metadata

Level in the ICD hierarchy 5
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 672 277 395
Unadjusted prevalence (%) 0.22 0.16 0.29
Mean age at first event (years) 46.65 44.49 48.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.11 8.57 [5.17, 14.22] 8.4e-17 74
15 years 0.03 4.22 [2.47, 7.21] 1.3e-7 34
5 years 0.01 8.53 [4.77, 15.23] 4.4e-13 30
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: H7_RETINOPATHYDIAB_BKG_SEVERE – Severe diabetic background retinopathy
GWS hits: 2

Survival analyses between endpoints

Plot

before Severe diabetic background retinopathy
after Severe diabetic background retinopathy

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Severe diabetic background retinopathy