Other diabetic retinopathy

H7_RETINOPATHYDIAB_NAS

diabetic retinopathy: A chronic, pathological complication associated with diabetes mellitus, where retinal damages are incurred due to microaneurysms in the vasculature of the retina, progressively leading to abnormal blood vessel growth, and swelling and leaking of fluid from blood vessels, resulting in vision loss or blindness.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H36.09*, H36.09*E10.3, H36.09*E11.3

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 H36.09*, H36.09*E10.3, H36.09*E11.3

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

1558

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1558

Check minimum number of events None

1558

Include endpoints None

1558

H7_RETINOPATHYDIAB_NAS

Extra metadata

Level in the ICD hierarchy 5

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other diabetic retinopathy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1526	752	774
Unadjusted prevalence (%)	0.49	0.43	0.57
Mean age at first event (years)	45.92	43.12	48.63

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	5.08 [2.54, 10.16]	4.3e-6	236
15 years	0.02	3.62 [2.22, 5.92]	2.8e-7	131
5 years	0.01	5.04 [3.46, 7.33]	3.6e-17	62
1 year	0.00	7.28 [4.22, 12.57]	1.1e-12	17

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_RETINOPATHYDIAB_NAS – Other diabetic retinopathy
GWS hits: 9

Survival analyses between endpoints

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Plot

before Other diabetic retinopathy
after Other diabetic retinopathy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other diabetic retinopathy

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