Secondary parkinsonism

PD2ND

secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G21

Hospital discharge: ICD-9 3321

Cause of death: ICD-10 G21

Cause of death: ICD-9 3321

586

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 9 ; C.O.D: 10, 9

586

Check minimum number of events None

586

Include endpoints None

586

PD2ND

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G20-G26

Name in latin Parkinsonismus secundarius

Similar endpoints

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List of similar endpoints to Secondary parkinsonism based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Other drug-induced secondary parkinsonism

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	569	239	330
Unadjusted prevalence (%)	0.18	0.14	0.24
Mean age at first event (years)	61.03	60.97	61.07

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	5.00 [3.08, 8.11]	8.0e-11	157
15 years	0.01	2.06 [1.23, 3.43]	5.9e-3	61
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: PD2ND – Secondary parkinsonism
GWS hits: 1

Survival analyses between endpoints

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Plot

before Secondary parkinsonism
after Secondary parkinsonism

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Table

Loading survival analyses table

Drugs most likely to be purchased after Secondary parkinsonism

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