Secondary parkinsonism


secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 G21
Hospital discharge: ICD-9 3321
Cause of death: ICD-10 G21
Cause of death: ICD-9 3321


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 9 ; C.O.D: 10, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Parkinsonismus secundarius

Summary Statistics

Key figures

All Female Male
Number of individuals 569 239 330
Unadjusted prevalence (%) 0.18 0.14 0.24
Mean age at first event (years) 61.03 60.97 61.07


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 5.00 [3.08, 8.11] 8.0e-11 157
15 years 0.01 2.06 [1.23, 3.43] 5.9e-3 61
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: PD2ND – Secondary parkinsonism
GWS hits: 1

Survival analyses between endpoints


before Secondary parkinsonism
after Secondary parkinsonism

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Drugs most likely to be purchased after Secondary parkinsonism