Secondary parkinsonism+Parkinsonism in other disease

G6_PARKSCND

postencephalitic Parkinson disease: Parkinsonism following encephalitis, historically seen as a sequella of encephalitis lethargica (Von Economo Encephalitis). The early age of onset, the rapid progression of symptoms followed by stabilization, and the presence of a variety of other neurological disorders (e.g., sociopathic behavior; TICS; MUSCLE SPASMS; oculogyric crises; hyperphagia; and bizarre movements) distinguish this condition from primary PARKINSON DISEASE. Pathologic features include neuronal loss and gliosis concentrated in the MESENCEPHALON; SUBTHALAMUS; and HYPOTHALAMUS. (From Adams et al., Principles of Neurology, 6th ed, p754)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G21, G22*, G22*A52.1

Hospital discharge: ICD-9 3321

Hospital discharge: ICD-8 3420[8-9]

Cause of death: ICD-10 G21, G22*, G22*A52.1

Cause of death: ICD-9 3321

Cause of death: ICD-8 3420[8-9]

609

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

609

Check minimum number of events None

609

Include endpoints None

609

G6_PARKSCND

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Secondary parkinsonism+Parkinsonism in other disease based on the number of shared cases.

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Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	590	246	344
Unadjusted prevalence (%)	0.19	0.14	0.25
Mean age at first event (years)	60.54	60.30	60.70

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	5.46 [3.58, 8.33]	3.6e-15	165
15 years	0.01	2.51 [1.77, 3.57]	2.6e-7	65
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_PARKSCND – Secondary parkinsonism+Parkinsonism in other disease
GWS hits: 1

Survival analyses between endpoints

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Plot

before Secondary parkinsonism+Parkinsonism in other disease
after Secondary parkinsonism+Parkinsonism in other disease

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Drugs most likely to be purchased after Secondary parkinsonism+Parkinsonism in other disease

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