Other overlap syndromes

M13_OVERLAP

mixed connective tissue disease: Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus , scleroderma , and polymyositis . Some affected people may also have symptoms of rheumatoid arthritis . Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) , corticosteroids and immunosuppresivedrugsmay help manage the symptoms.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M35.1

Hospital discharge: ICD-9 $!$

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 M35.1

Cause of death: ICD-9 $!$

Cause of death: ICD-8 $!$

403

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

403

Check minimum number of events None

403

Include endpoints None

403

M13_OVERLAP

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M35

Name in latin Alia syndromata mixta

Similar endpoints

↥

List of similar endpoints to Other overlap syndromes based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	391	310	81
Unadjusted prevalence (%)	0.13	0.18	0.06
Mean age at first event (years)	51.90	50.40	57.62

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.99 [2.23, 7.15]	3.1e-6	31
15 years	0.01	2.27 [1.27, 4.04]	5.6e-3	15
5 years	0.01	5.02 [2.60, 9.69]	1.5e-6	11
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: M13_OVERLAP – Other overlap syndromes
GWS hits: 0

Survival analyses between endpoints

↥

Plot

before Other overlap syndromes
after Other overlap syndromes

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other overlap syndromes

↥