Other overlap syndromes


mixed connective tissue disease: Mixed connective tissue disease (MCTD) is a rare autoimmune disorder that is characterized by features commonly seen in three different connective tissue disorders: systemic lupus erythematosus , scleroderma , and polymyositis . Some affected people may also have symptoms of rheumatoid arthritis . Although MCTD can affect people of all ages, it appears to be most common in women under age 30. Signs and symptoms vary but may include Raynaud's phenomenon ; arthritis; heart, lung and skin abnormalities; kidney disease; muscle weakness, and dysfunction of the esophagus. The cause of MCTD is currently unknown. There is no cure but certain medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) , corticosteroids and immunosuppresivedrugsmay help manage the symptoms.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 M35.1
Hospital discharge: ICD-9 $!$
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 M35.1
Cause of death: ICD-9 $!$
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M35
Name in latin Alia syndromata mixta

Summary Statistics

Key figures

All Female Male
Number of individuals 391 310 81
Unadjusted prevalence (%) 0.13 0.18 0.06
Mean age at first event (years) 51.90 50.40 57.62


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.99 [2.23, 7.15] 3.1e-6 31
15 years 0.01 2.27 [1.27, 4.04] 5.6e-3 15
5 years 0.01 5.02 [2.60, 9.69] 1.5e-6 11
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: M13_OVERLAP – Other overlap syndromes
GWS hits: 0

Survival analyses between endpoints


before Other overlap syndromes
after Other overlap syndromes

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Drugs most likely to be purchased after Other overlap syndromes