Mixed connective tissue disease

PheWeb

M13_MCTD

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M35.9

Hospital discharge: ICD-9 7109

Hospital discharge: ICD-8 73499

Cause of death: ICD-10 M35.9

Cause of death: ICD-9 7109

Cause of death: ICD-8 73499

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints

M13_OVERLAP

1497

M13_MCTD

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF7

Similar endpoints

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List of similar endpoints to Mixed connective tissue disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Other overlap syndromes

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1452	1159	293
Unadjusted prevalence (%)	0.47	0.67	0.22
Mean age at first event (years)	50.78	49.32	56.57

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.79 [1.72, 4.53]	3.3e-5	109
15 years	0.01	1.49 [0.86, 2.58]	1.5e-1	51
5 years	0.00	2.57 [1.51, 4.40]	5.4e-4	31
1 year	0.00	5.27 [2.84, 9.76]	1.3e-7	13

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_MCTD – Mixed connective tissue disease
GWS hits:

Survival analyses between endpoints

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Plot

before Mixed connective tissue disease
after Mixed connective tissue disease

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Table

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Drugs most likely to be purchased after Mixed connective tissue disease

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