Gonarthrosis

M13_ARTHROSIS_KNEE

spondyloarthropathy: A group of inflammatory rheumatic diseases associated with arthritis and enthesitis, and often involving the axial skeleton. The most common form of spondyloarthritis is ankylosing spondylitis. Other forms include axial spondyloarthritis, peripheral spondyloarthritis, reactive arthritis, psoriatic arthritis/spondylitis and enteropathic arthritis/spondylitis.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M17

Hospital discharge: ICD-9 7151F|7152F

Hospital discharge: ICD-8 71301

Cause of death: ICD-10 M17

Cause of death: ICD-9 7151F|7152F

Cause of death: ICD-8 71301

35334

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

35334

Check minimum number of events None

35334

Include endpoints None

35334

M13_ARTHROSIS_KNEE

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 M15-M19

Name in latin Gonarthrosis

Similar endpoints

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List of similar endpoints to Gonarthrosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	34417	20358	14059
Unadjusted prevalence (%)	11.15	11.73	10.41
Mean age at first event (years)	59.07	59.18	58.91

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	1.08 [0.95, 1.23]	2.4e-1	3022
15 years	0.00	0.80 [0.72, 0.90]	1.5e-4	1574
5 years	0.00	1.24 [1.11, 1.39]	2.4e-4	655
1 year	0.00	1.43 [1.17, 1.74]	4.2e-4	140

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_ARTHROSIS_KNEE – Gonarthrosis
GWS hits: 20

Survival analyses between endpoints

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Plot

before Gonarthrosis
after Gonarthrosis

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Gonarthrosis

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