Radiation-related disorders of the skin and subcutaneous tissue

L12_RADIATIONRELATEDSKIN

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 L55-L59

Cause of death: ICD-10 L55-L59

8562

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

8562

Check minimum number of events None

8562

Include endpoints

L12_SUNBURN

L12_OTHACUSKINSUN

L12_NONIONRADISKIN

L12_RADIODERMATITIS

L12_SKINRADIOTH

9009

L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

↥

List of similar endpoints to Radiation-related disorders of the skin and subcutaneous tissue based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	8749	4581	4168
Unadjusted prevalence (%)	2.84	2.64	3.09
Mean age at first event (years)	68.05	66.95	69.26

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.79 [1.44, 2.22]	1.3e-7	894
15 years	0.01	0.92 [0.75, 1.13]	4.3e-1	395
5 years	0.00	2.01 [1.71, 2.37]	9.4e-17	362
1 year	0.00	1.93 [1.47, 2.53]	1.8e-6	72

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: L12_RADIATIONRELATEDSKIN – Radiation-related disorders of the skin and subcutaneous tissue
GWS hits: 14

Survival analyses between endpoints

↥

Plot

before Radiation-related disorders of the skin and subcutaneous tissue
after Radiation-related disorders of the skin and subcutaneous tissue

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Radiation-related disorders of the skin and subcutaneous tissue

↥