Radiation-related disorders of the skin and subcutaneous tissue

L12_RADIATIONRELATEDSKIN

phototoxic dermatitis: a form of allergic contact dermatitis in which the allergen must be activated by light to sensitize the allergic response, and to cause a rash or other systemic effects on subsequent exposure. The second and subsequent exposures produce photoallergic skin conditions which are often eczematous. In rare cases the victims die.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 L55-L59

Cause of death: ICD-10 L55-L59

8562

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

8562

Check minimum number of events None

8562

Include endpoints

L12_SUNBURN

L12_OTHACUSKINSUN

L12_NONIONRADISKIN

L12_RADIODERMATITIS

L12_SKINRADIOTH

9009

L12_RADIATIONRELATEDSKIN

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Radiation-related disorders of the skin and subcutaneous tissue based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

8749

4581

4168

Unadjusted prevalence (%)

2.84

2.64

3.09

Mean age at first event (years)

68.05

66.95

69.26

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Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.79 [1.44, 2.22]	1.3e-7	894
15 years	0.01	0.92 [0.75, 1.13]	4.3e-1	395
5 years	0.00	2.01 [1.71, 2.37]	9.4e-17	362
1 year	0.00	1.93 [1.47, 2.53]	1.8e-6	72

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_RADIATIONRELATEDSKIN – Radiation-related disorders of the skin and subcutaneous tissue
GWS hits: 14

Survival analyses between endpoints

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Plot

before Radiation-related disorders of the skin and subcutaneous tissue
after Radiation-related disorders of the skin and subcutaneous tissue

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Table

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Drugs most likely to be purchased after Radiation-related disorders of the skin and subcutaneous tissue

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