Actinic keratosis

L12_ACTINKERA

actinic keratosis: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 L57.0

Hospital discharge: ICD-9 7020A

Hospital discharge: ICD-8 70200

Cause of death: ICD-10 L57.0

Cause of death: ICD-9 7020A

Cause of death: ICD-8 70200

7926

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7926

Check minimum number of events None

7926

Include endpoints None

7926

L12_ACTINKERA

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 L57

Name in latin Keratosis actinica

Similar endpoints

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List of similar endpoints to Actinic keratosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	7698	3956	3742
Unadjusted prevalence (%)	2.49	2.28	2.77
Mean age at first event (years)	71.47	70.55	72.45

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.33 [0.98, 1.79]	6.3e-2	770
15 years	0.00	0.71 [0.55, 0.90]	5.7e-3	332
5 years	0.00	1.73 [1.42, 2.11]	7.2e-8	338
1 year	0.00	1.70 [1.27, 2.28]	3.2e-4	67

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: L12_ACTINKERA – Actinic keratosis
GWS hits: 15

Survival analyses between endpoints

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Plot

before Actinic keratosis
after Actinic keratosis

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Table

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Drugs most likely to be purchased after Actinic keratosis

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