Actinic keratosis


actinic keratosis: A precancerous lesion of the skin composed of atypical keratinocytes. It is characterized by the presence of thick, scaly patches of skin. Several histologic variants have been described, including atrophic, acantholytic, and hyperkeratotic variants.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 L57.0
Hospital discharge: ICD-9 7020A
Hospital discharge: ICD-8 70200
Cause of death: ICD-10 L57.0
Cause of death: ICD-9 7020A
Cause of death: ICD-8 70200


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 L57
Name in latin Keratosis actinica

Summary Statistics

Key figures

All Female Male
Number of individuals 7698 3956 3742
Unadjusted prevalence (%) 2.49 2.28 2.77
Mean age at first event (years) 71.47 70.55 72.45


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.33 [0.98, 1.79] 6.3e-2 770
15 years 0.00 0.71 [0.55, 0.90] 5.7e-3 332
5 years 0.00 1.73 [1.42, 2.11] 7.2e-8 338
1 year 0.00 1.70 [1.27, 2.28] 3.2e-4 67

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: L12_ACTINKERA – Actinic keratosis
GWS hits: 15

Survival analyses between endpoints


before Actinic keratosis
after Actinic keratosis

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Drugs most likely to be purchased after Actinic keratosis