Gastro-oesophageal reflux disease


gastroesophageal reflux disease: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 K21
Hospital discharge: ICD-9 5301A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 K21
Cause of death: ICD-9 5301A
Cause of death: ICD-8 $!$


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 K20-K31
Name in latin Morbus refluxualis gastro-oesophageus

Summary Statistics

Key figures

All Female Male
Number of individuals 19912 11547 8365
Unadjusted prevalence (%) 6.45 6.65 6.20
Mean age at first event (years) 54.53 53.65 55.73


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.54 [1.30, 1.84] 1.1e-6 1463
15 years 0.01 0.98 [0.83, 1.16] 7.9e-1 683
5 years 0.00 2.17 [1.86, 2.54] 1.7e-22 427
1 year 0.00 4.20 [3.41, 5.16] 7.4e-42 156

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: K11_REFLUX – Gastro-oesophageal reflux disease
GWS hits: 1

Survival analyses between endpoints


before Gastro-oesophageal reflux disease
after Gastro-oesophageal reflux disease

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Drugs most likely to be purchased after Gastro-oesophageal reflux disease