Gastro-oesophageal reflux disease

K11_REFLUX

gastroesophageal reflux disease: A chronic disorder characterized by reflux of the gastric and/or duodenal contents into the distal esophagus. It is usually caused by incompetence of the lower esophageal sphincter. Symptoms include heartburn and acid indigestion. It may cause injury to the esophageal mucosa.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K21

Hospital discharge: ICD-9 5301A

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 K21

Cause of death: ICD-9 5301A

Cause of death: ICD-8 $!$

20608

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

20608

Check minimum number of events None

20608

Include endpoints None

20608

K11_REFLUX

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K20-K31

Name in latin Morbus refluxualis gastro-oesophageus

Similar endpoints

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List of similar endpoints to Gastro-oesophageal reflux disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	19912	11547	8365
Unadjusted prevalence (%)	6.45	6.65	6.20
Mean age at first event (years)	54.53	53.65	55.73

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.54 [1.30, 1.84]	1.1e-6	1463
15 years	0.01	0.98 [0.83, 1.16]	7.9e-1	683
5 years	0.00	2.17 [1.86, 2.54]	1.7e-22	427
1 year	0.00	4.20 [3.41, 5.16]	7.4e-42	156

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_REFLUX – Gastro-oesophageal reflux disease
GWS hits: 1

Survival analyses between endpoints

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Plot

before Gastro-oesophageal reflux disease
after Gastro-oesophageal reflux disease

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Table

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Drugs most likely to be purchased after Gastro-oesophageal reflux disease

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