Stroke, excluding SAH

I9_STR

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I61, I63, I64

Hospital discharge: ICD-9 431|4330A|4331A|4339A|4340A|4341A|4349A|436

Hospital discharge: ICD-8 431|433|434|436

Hospital discharge: excluded ICD-10 I63.6

Hospital discharge: excluded ICD-8 43101|43191

Cause of death: ICD-10 I61, I63, I64

Cause of death: ICD-9 431|4330A|4331A|4339A|4340A|4341A|4349A|436

Cause of death: ICD-8 431|433|434|436

Cause of death: excluded ICD-10 I63.6

Cause of death: excluded ICD-8 43101|43191

19475

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

19386

Check minimum number of events None

19386

Include endpoints None

19386

I9_STR

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Stroke, excluding SAH based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	18720	7319	11401
Unadjusted prevalence (%)	6.07	4.22	8.44
Mean age at first event (years)	66.39	66.19	66.52

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.55 [4.04, 5.12]	<1e-100	6180
15 years	0.01	1.94 [1.72, 2.18]	9.1e-27	1996
5 years	0.01	4.51 [4.10, 4.96]	<1e-100	1749
1 year	0.00	22.09 [19.70, 24.78]	<1e-100	2014

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_STR – Stroke, excluding SAH
GWS hits: 1

Survival analyses between endpoints

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Plot

before Stroke, excluding SAH
after Stroke, excluding SAH

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Table

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Drugs most likely to be purchased after Stroke, excluding SAH

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