Ischaemic Stroke, excluding all haemorrhages

I9_STR_EXH

cerebrovascular disorder: A disorder resulting from inadequate blood flow in the vessels that supply the brain. Representative examples include cerebrovascular ischemia, cerebral embolism, and cerebral infarction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I63, I64

Hospital discharge: ICD-9 4330A|4331A|4339A|4340A|4341A|4349A|436

Hospital discharge: ICD-8 433|434|436

Hospital discharge: excluded ICD-10 I63.6

Cause of death: ICD-10 I63, I64

Cause of death: ICD-9 4330A|4331A|4339A|4340A|4341A|4349A|436

Cause of death: ICD-8 433|434|436

Cause of death: excluded ICD-10 I63.6

17536

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

17448

Check minimum number of events None

17448

Include endpoints

I9_STR_EMBOLIC

17448

I9_STR_EXH

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Ischaemic Stroke, excluding all haemorrhages based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

16857

6600

10257

Unadjusted prevalence (%)

5.46

3.80

7.60

Mean age at first event (years)

66.54

66.35

66.66

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.43 [3.92, 5.01]	<1e-100	5440
15 years	0.01	1.99 [1.78, 2.23]	4.4e-32	1867
5 years	0.00	4.25 [3.86, 4.67]	<1e-100	1620
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_STR_EXH – Ischaemic Stroke, excluding all haemorrhages
GWS hits: 2

Survival analyses between endpoints

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Plot

before Ischaemic Stroke, excluding all haemorrhages
after Ischaemic Stroke, excluding all haemorrhages

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Ischaemic Stroke, excluding all haemorrhages

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