Other pulmonary heart/vessel disease

I9_PULMOTHHD

pulmonary arterial hypertension: Pulmonary arterial hypertension (PAH) is a group of diseases characterized by elevated pulmonary arterial resistance leading to right heart failure. PAH is progressive and potentially fatal. PAH may be idiopathic and/ or familial, or induced by drug or toxin (drug-or toxin-induced PAH, see these terms) or associated with other diseases like congenital heart disease, connective tissue disease, HIV, schistosomiasis, portal hypertension (PAH associated with other disease, see this term).

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I27, I28

Hospital discharge: ICD-9 416|417

Hospital discharge: ICD-8 426

Cause of death: ICD-10 I27, I28

Cause of death: ICD-9 416|417

Cause of death: ICD-8 426

1265

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

915

Check minimum number of events None

915

Include endpoints

I9_SECONDRIGHT

915

I9_PULMOTHHD

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other pulmonary heart/vessel disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	894	422	472
Unadjusted prevalence (%)	0.29	0.24	0.35
Mean age at first event (years)	64.05	62.05	65.84

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_PULMOTHHD – Other pulmonary heart/vessel disease
GWS hits: 0

Survival analyses between endpoints

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Plot

before Other pulmonary heart/vessel disease
after Other pulmonary heart/vessel disease

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other pulmonary heart/vessel disease

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