Heart failure,strict


systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

FinnGen phenotype data

321302 individuals

diagram downward connector

Apply sex-specific rule None


diagram downward connector

Check conditions None


diagram downward connector
diagram bullet

Filter registries

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50
Hospital discharge: ICD-9 4029B|428
Hospital discharge: ICD-8 42700|42710|428|7824
Cause of death: ICD-10 I11.0, I13.0, I13.2, I50
Cause of death: ICD-9 4029B|428
Cause of death: ICD-8 42700|42710|428|7824
KELA reimbursements: KELA codes 201
Medicine purchases: ATC C03CA01|C03EB01


diagram downward connector
diagram bullet

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


diagram downward connector
diagram bullet

Check minimum number of events

Min. number of events 3, and need other rules


diagram downward connector

Include endpoints None


diagram downward connector

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF6

Summary Statistics

Key figures

All Female Male
Number of individuals 19676 7419 12257
Unadjusted prevalence (%) 6.38 4.28 9.08
Mean age at first event (years) 68.69 69.14 68.41


Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_HEARTFAIL – Heart failure,strict
GWS hits: 2

Survival analyses between endpoints


before Heart failure,strict
after Heart failure,strict

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Heart failure,strict