Heart failure,strict

I9_HEARTFAIL

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50

Hospital discharge: ICD-9 4029B|428

Hospital discharge: ICD-8 42700|42710|428|7824

Cause of death: ICD-10 I11.0, I13.0, I13.2, I50

Cause of death: ICD-9 4029B|428

Cause of death: ICD-8 42700|42710|428|7824

KELA reimbursements: KELA codes 201

Medicine purchases: ATC C03CA01|C03EB01

20391

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

20338

Check minimum number of events

Min. number of events 3, and need other rules

20338

Include endpoints None

20338

I9_HEARTFAIL

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF6

Similar endpoints

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List of similar endpoints to Heart failure,strict based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	19676	7419	12257
Unadjusted prevalence (%)	6.38	4.28	9.08
Mean age at first event (years)	68.69	69.14	68.41

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HEARTFAIL – Heart failure,strict
GWS hits: 2

Survival analyses between endpoints

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Plot

before Heart failure,strict
after Heart failure,strict

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Table

Loading survival analyses table

Drugs most likely to be purchased after Heart failure,strict

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