Heart failure, not strict

I9_HEARTFAIL_NS

systolic heart failure: Heart failure caused by abnormal myocardial contraction during systole leading to defective cardiac emptying.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I11.0, I13.0, I13.2, I50

Hospital discharge: ICD-9 4029B|428

Hospital discharge: ICD-8 42700|42710|428|7824

Cause of death: ICD-10 I11.0, I13.0, I13.2, I50

Cause of death: ICD-9 4029B|428

Cause of death: ICD-8 42700|42710|428|7824

KELA reimbursements: KELA codes 201

Medicine purchases: ATC C03CA01|C03EB01

51921

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

38019

Check minimum number of events

Min. number of events 3

38019

Include endpoints None

38019

I9_HEARTFAIL_NS

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF6

Similar endpoints

↥

List of similar endpoints to Heart failure, not strict based on the number of shared cases.

Broader endpoints:

None

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	36783	16388	20395
Unadjusted prevalence (%)	11.92	9.44	15.10
Mean age at first event (years)	66.37	65.14	67.36

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.07	5.39 [4.92, 5.89]	<1e-100	11733
15 years	0.02	2.95 [2.69, 3.22]	<1e-100	4783
5 years	0.02	224.62 [82.33, 612.82]	4.0e-26	4106
1 year	0.00	11.74 [10.45, 13.20]	<1e-100	2075

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: I9_HEARTFAIL_NS – Heart failure, not strict
GWS hits: 3

Survival analyses between endpoints

↥

Plot

before Heart failure, not strict
after Heart failure, not strict

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Heart failure, not strict

↥