Calcific aortic valvular stenosis, including rheumatic fever

PheWeb

I9_CAVS_RHEU

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I06.0, I06.2, I35.0, I35.2

Hospital discharge: ICD-9 3950A|3952A|4241[BC]

Hospital discharge: ICD-8 39500|39502

Cause of death: ICD-10 I06.0, I06.2, I35.0, I35.2

Cause of death: ICD-9 3950A|3952A|4241[BC]

Cause of death: ICD-8 39500|39502

7125

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7125

Check minimum number of events None

7125

Include endpoints None

7125

I9_CAVS_RHEU

Extra metadata

First used in FinnGen datafreeze DF6v3

Similar endpoints

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List of similar endpoints to Calcific aortic valvular stenosis, including rheumatic fever based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	6907	2654	4253
Unadjusted prevalence (%)	2.24	1.53	3.15
Mean age at first event (years)	70.35	71.60	69.57

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.20 [3.59, 4.90]	1.6e-73	1699
15 years	0.01	1.73 [1.47, 2.04]	4.2e-11	635
5 years	0.00	3.18 [2.71, 3.74]	2.6e-45	569
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CAVS_RHEU – Calcific aortic valvular stenosis, including rheumatic fever
GWS hits:

Survival analyses between endpoints

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Plot

before Calcific aortic valvular stenosis, including rheumatic fever
after Calcific aortic valvular stenosis, including rheumatic fever

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Table

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Drugs most likely to be purchased after Calcific aortic valvular stenosis, including rheumatic fever

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