Atherosclerosis, excluding cerebral, coronary and PAD

I9_ATHSCLE

atherosclerosis: Build-up of fatty material and calcium deposition in the arterial wall resulting in partial or complete occlusion of the arterial lumen.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I70

Hospital discharge: ICD-9 440|4370|4371X

Hospital discharge: ICD-8 440

Cause of death: ICD-10 I70

Cause of death: ICD-9 440|4370|4371X

Cause of death: ICD-8 440

11492

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

11485

Check minimum number of events None

11485

Include endpoints None

11485

I9_ATHSCLE

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 I70-I79

Name in latin Atherosclerosis

Similar endpoints

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List of similar endpoints to Atherosclerosis, excluding cerebral, coronary and PAD based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	11189	3454	7735
Unadjusted prevalence (%)	3.63	1.99	5.73
Mean age at first event (years)	67.62	68.30	67.32

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.22 [3.57, 4.99]	1.4e-63	4106
15 years	0.01	2.24 [1.95, 2.58]	1.8e-29	1639
5 years	0.01	4.41 [3.97, 4.90]	<1e-100	1321
1 year	0.00	13.39 [11.79, 15.22]	<1e-100	899

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_ATHSCLE – Atherosclerosis, excluding cerebral, coronary and PAD
GWS hits: 6

Survival analyses between endpoints

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Plot

before Atherosclerosis, excluding cerebral, coronary and PAD
after Atherosclerosis, excluding cerebral, coronary and PAD

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Table

Loading survival analyses table

Drugs most likely to be purchased after Atherosclerosis, excluding cerebral, coronary and PAD

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