Other disorders of cornea

H7_CORNEALOTH

corneal disease: A non-neoplastic or neoplastic disorder that affects the cornea. Representative examples include keratitis, bullous keratopathy, and squamous cell carcinoma.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H18

Cause of death: ICD-10 H18

1838

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

1838

Check minimum number of events None

1838

Include endpoints

H7_CORNEAPIGMENT

H7_BULLKERATOPATHY

H7_CORNEALOEDEMA

H7_CORNEALMEMBRANE

H7_CORNEALDYSTROPHY

H7_KERATOCONUS

H7_CORNEALDEFORM

H7_CORNEALNAS

1915

H7_CORNEALOTH

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H15-H22

Name in latin Aliae morbositates corneae

Similar endpoints

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List of similar endpoints to Other disorders of cornea based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1853	1056	797
Unadjusted prevalence (%)	0.60	0.61	0.59
Mean age at first event (years)	53.66	54.72	52.25

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	2.92 [1.93, 4.41]	3.6e-7	132
15 years	0.01	1.55 [1.04, 2.30]	3.3e-2	60
5 years	0.00	3.34 [2.24, 4.98]	3.2e-9	49
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_CORNEALOTH – Other disorders of cornea
GWS hits: 2

Survival analyses between endpoints

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Plot

before Other disorders of cornea
after Other disorders of cornea

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Table

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Drugs most likely to be purchased after Other disorders of cornea

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