Keratoconus

DOID MESH PheWeb

H7_CORNEALDEFORM

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H18.6

Hospital discharge: ICD-9 3716

Hospital discharge: ICD-8 37103

Cause of death: ICD-10 H18.6

Cause of death: ICD-9 3716

Cause of death: ICD-8 37103

504

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

504

Check minimum number of events None

504

Include endpoints None

504

H7_CORNEALDEFORM

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H18

Name in latin Keratoconus

Similar endpoints

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List of similar endpoints to Keratoconus based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	483	206	277
Unadjusted prevalence (%)	0.16	0.12	0.21
Mean age at first event (years)	43.52	45.56	42.00

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.51 [0.54, 4.22]	4.3e-1	19
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_CORNEALDEFORM – Keratoconus
GWS hits: 1

Survival analyses between endpoints

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Plot

before Keratoconus
after Keratoconus

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Keratoconus

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