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Disorders of sclera, cornea, iris and ciliary body

DOIDEFOMESHSNOMED PheWeb

H7_SCLERACORNEA

corneal neovascularization: New blood vessels originating from the corneal veins and extending from the limbus into the adjacent corneal stroma. Neovascularization in the superficial and/or deep corneal stroma is a sequel to numerous inflammatory diseases of the ocular anterior segment, such as trachoma, viral interstitial keratitis, microbial keratoconjunctivitis, and the immune response elicited by corneal transplantation.

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 H15-H22, H22.0*B96.80
Cause of death: ICD-10 H15-H22, H22.0*B96.80

14527

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

14527

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Check minimum number of events None

14527

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Include endpoints

15178

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H7_SCLERACORNEA

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 14640 8243 6397
Unadjusted prevalence (%) 4.74 4.75 4.74
Mean age at first event (years) 49.43 48.87 50.17

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.75 [1.40, 2.18] 7.4e-7 985
15 years 0.01 1.12 [0.92, 1.37] 2.4e-1 455
5 years 0.00 2.37 [1.98, 2.82] 8.9e-22 294
1 year 0.00 3.96 [3.09, 5.08] 2.1e-27 96

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_SCLERACORNEA – Disorders of sclera, cornea, iris and ciliary body
GWS hits: 13

Survival analyses between endpoints

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Plot

before Disorders of sclera, cornea, iris and ciliary body
after Disorders of sclera, cornea, iris and ciliary body

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Drugs most likely to be purchased after Disorders of sclera, cornea, iris and ciliary body

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