Hereditary corneal dystrophies

DOID MESH PheWeb

H7_KERATOCONUS

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 H18.5

Hospital discharge: ICD-9 3715

Hospital discharge: ICD-8 37102

Cause of death: ICD-10 H18.5

Cause of death: ICD-9 3715

Cause of death: ICD-8 37102

541

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

541

Check minimum number of events None

541

Include endpoints None

541

H7_KERATOCONUS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 H18

Name in latin Dystrophia corneae hereditaria

Similar endpoints

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List of similar endpoints to Hereditary corneal dystrophies based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	532	357	175
Unadjusted prevalence (%)	0.17	0.21	0.13
Mean age at first event (years)	62.12	62.14	62.09

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.01	0.89 [0.25, 3.19]	8.6e-1	31
15 years	0.01	0.98 [0.33, 2.95]	9.7e-1	20
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: H7_KERATOCONUS – Hereditary corneal dystrophies
GWS hits: 3

Survival analyses between endpoints

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Plot

before Hereditary corneal dystrophies
after Hereditary corneal dystrophies

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Table

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Drugs most likely to be purchased after Hereditary corneal dystrophies

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