Motor neuron disease

DOID EFO MESH SNOMED PheWeb

G6_ALS

motor neuron disease: A disease involving the motor neuron.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G12.2

Hospital discharge: ICD-9 3352A

Hospital discharge: ICD-8 348[0-1]|34821

Cause of death: ICD-10 G12.2

Cause of death: ICD-9 3352A

Cause of death: ICD-8 348[0-1]|34821

391

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

361

Check minimum number of events None

361

Include endpoints None

361

G6_ALS

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G12

Name in latin Morbus motoneuronalis

Similar endpoints

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List of similar endpoints to Motor neuron disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	355	134	221
Unadjusted prevalence (%)	0.12	0.08	0.16
Mean age at first event (years)	64.70	64.01	65.12

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_ALS – Motor neuron disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Motor neuron disease
after Motor neuron disease

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Table

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Drugs most likely to be purchased after Motor neuron disease

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