Systemic atrophies primarly affecting the central nervous system

DOID MESH PheWeb

G6_NEUATR

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G10-G13

Cause of death: ICD-10 G10-G13

719

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

719

Check minimum number of events None

719

Include endpoints

G6_HUNTINGTON

G6_HERATAXIA

G6_INFAMUSC

G6_OTHINMUSC

G6_ALS

G6_SPINAMUSCOTH

G6_POSTPOLIO

851

G6_NEUATR

Extra metadata

Level in the ICD hierarchy 2

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Systemic atrophies primarly affecting the central nervous system based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	830	347	483
Unadjusted prevalence (%)	0.27	0.20	0.36
Mean age at first event (years)	57.30	54.31	59.45

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.10	7.44 [5.35, 10.34]	8.2e-33	241
15 years	0.02	2.44 [1.74, 3.43]	2.7e-7	66
5 years	0.01	7.40 [5.00, 10.95]	1.4e-23	74
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_NEUATR – Systemic atrophies primarly affecting the central nervous system
GWS hits: 5

Survival analyses between endpoints

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Plot

before Systemic atrophies primarly affecting the central nervous system
after Systemic atrophies primarly affecting the central nervous system

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Table

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Drugs most likely to be purchased after Systemic atrophies primarly affecting the central nervous system

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