Other inherited muscular atrophy

G6_OTHINMUSC

amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 G12.1
Hospital discharge: ICD-9 3351A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 G12.1
Cause of death: ICD-9 3351A
Cause of death: ICD-8 $!$

36

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

36

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Check minimum number of events None

36

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Include endpoints None

36

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G6_OTHINMUSC

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G12
Name in latin Alia atrophia musculorum spinalis congenita

Summary Statistics

Key figures

All Female Male
Number of individuals 35 14 21
Unadjusted prevalence (%) 0.01 0.01 0.02
Mean age at first event (years) 53.72 52.74 54.38

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 - - - -
15 years - - - -
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: G6_OTHINMUSC – Other inherited muscular atrophy
GWS hits:

Survival analyses between endpoints

Plot

before Other inherited muscular atrophy
after Other inherited muscular atrophy

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Drugs most likely to be purchased after Other inherited muscular atrophy