Other inherited muscular atrophy

G6_OTHINMUSC

amyotrophic lateral sclerosis: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscular paralysis reflecting degeneration of motor neurons in the primary motor cortex, corticospinal tracts, brainstem and spinal cord.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G12.1

Hospital discharge: ICD-9 3351A

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 G12.1

Cause of death: ICD-9 3351A

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

G6_OTHINMUSC

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G12

Name in latin Alia atrophia musculorum spinalis congenita

Similar endpoints

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List of similar endpoints to Other inherited muscular atrophy based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	35	14	21
Unadjusted prevalence (%)	0.01	0.01	0.02
Mean age at first event (years)	53.72	52.74	54.38

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_OTHINMUSC – Other inherited muscular atrophy
GWS hits:

Survival analyses between endpoints

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Plot

before Other inherited muscular atrophy
after Other inherited muscular atrophy

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Other inherited muscular atrophy

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