Hypertensive diseases (excluding secondary)

FG_HYPERTENSION

hypertension: Persistently high systemic arterial blood pressure. Based on multiple readings (blood pressure determination), hypertension is currently defined as when systolic pressure is consistently greater than 140 mm Hg or when diastolic pressure is consistently 90 mm Hg or more.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries None

0

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Check pre-conditions, main-only, mode, ICD version None

0

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Check minimum number of events None

0

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FG_HYPERTENSION

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 85491 41601 43890
Unadjusted prevalence (%) 27.71 23.97 32.51
Mean age at first event (years) 56.97 56.82 57.11

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.02 1.77 [1.64, 1.91] 4.5e-48 12851
15 years 0.01 1.05 [0.97, 1.13] 2.2e-1 5419
5 years 0.00 1.72 [1.60, 1.85] 9.8e-48 2649
1 year 0.00 6.77 [6.08, 7.55] <1e-100 1871

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: FG_HYPERTENSION – Hypertensive diseases (excluding secondary)
GWS hits: 84

Survival analyses between endpoints

Plot

before Hypertensive diseases (excluding secondary)
after Hypertensive diseases (excluding secondary)

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertensive diseases (excluding secondary)