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Hypertensive heart and/or renal disease

DOIDEFOMESHSNOMED PheWeb

I9_HYPTENSHR

nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)

Endpoint definition

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FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 I11, I12, I13
Hospital discharge: ICD-9 4029A|4029B|4039A|4040A
Hospital discharge: ICD-8 40299|40399|40499
Cause of death: ICD-10 I11, I12, I13
Cause of death: ICD-9 4029A|4029B|4039A|4040A
Cause of death: ICD-8 40299|40399|40499

7464

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7464

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Check minimum number of events None

7464

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Include endpoints

7464

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I9_HYPTENSHR

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Summary Statistics

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Key figures

All Female Male
Number of individuals 7222 2872 4350
Unadjusted prevalence (%) 2.34 1.66 3.22
Mean age at first event (years) 66.08 68.08 64.77

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 3.75 [2.99, 4.70] 2.9e-30 2428
15 years 0.01 1.56 [1.29, 1.88] 3.7e-6 796
5 years 0.00 0.10 [0.01, 0.83] 3.3e-2 600
1 year 0.00 21.48 [18.62, 24.76] <1e-100 876

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_HYPTENSHR – Hypertensive heart and/or renal disease
GWS hits: 4

Survival analyses between endpoints

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Plot

before Hypertensive heart and/or renal disease
after Hypertensive heart and/or renal disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertensive heart and/or renal disease

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