Hypertensive Renal Disease


nephrosclerosis: Hardening of the walls of the small arteries and arterioles (small arteries that convey blood from arteries to the even smaller capillaries) of the kidney. This condition is caused by hypertension (high blood pressure)

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 I12
Hospital discharge: ICD-9 4039A
Hospital discharge: ICD-8 40399
Cause of death: ICD-10 I12
Cause of death: ICD-9 4039A
Cause of death: ICD-8 40399


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 I10-I15
Name in latin Morbus hypertensivus renalis

Summary Statistics

Key figures

All Female Male
Number of individuals 777 260 517
Unadjusted prevalence (%) 0.25 0.15 0.38
Mean age at first event (years) 60.60 58.56 61.62


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 4.25 [2.84, 6.38] 2.5e-12 225
15 years 0.01 1.34 [0.89, 2.03] 1.6e-1 60
5 years 0.00 3.56 [2.36, 5.37] 1.4e-9 65
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: I9_HYPTENSRD – Hypertensive Renal Disease
GWS hits: 0

Survival analyses between endpoints


before Hypertensive Renal Disease
after Hypertensive Renal Disease

loading spinner Loading survival analyses plot

Drugs most likely to be purchased after Hypertensive Renal Disease