Mixed hyperlipidaemia

E4_HYPERLIPMIX

obsolete_familial combined hyperlipidemia: ['A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E78.2

Hospital discharge: ICD-9 2722

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E78.2

Cause of death: ICD-9 2722

Cause of death: ICD-8 $!$

882

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

882

Check minimum number of events None

882

Include endpoints None

882

E4_HYPERLIPMIX

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E78

Similar endpoints

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List of similar endpoints to Mixed hyperlipidaemia based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	849	307	542
Unadjusted prevalence (%)	0.28	0.18	0.40
Mean age at first event (years)	55.70	56.34	55.34

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.03 [1.58, 5.80]	8.4e-4	138
15 years	0.01	2.23 [1.16, 4.30]	1.7e-2	76
5 years	0.00	3.66 [2.13, 6.28]	2.5e-6	33
1 year	0.00	5.98 [2.86, 12.48]	1.9e-6	10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYPERLIPMIX – Mixed hyperlipidaemia
GWS hits: 3

Survival analyses between endpoints

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Plot

before Mixed hyperlipidaemia
after Mixed hyperlipidaemia

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Table

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Drugs most likely to be purchased after Mixed hyperlipidaemia

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