Cushing syndrome

E4_CUSHING

hyperaldosteronism: Overproduction of aldosterone by the adrenal glands, which may lead to hypokalemia and/or hypernatremia. [ NCIT:P378 ]

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E24

Hospital discharge: ICD-9 2550|2593

Hospital discharge: ICD-8 2580

Cause of death: ICD-10 E24

Cause of death: ICD-9 2550|2593

Cause of death: ICD-8 2580

284

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

241

Check minimum number of events None

241

Include endpoints None

241

E4_CUSHING

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF6

Parent code in ICD-10 E20-E35

Name in latin Syndroma Cushing

Similar endpoints

↥

List of similar endpoints to Cushing syndrome based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	233	163	70
Unadjusted prevalence (%)	0.08	0.09	0.05
Mean age at first event (years)	46.21	44.18	50.92

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.03	2.89 [1.09, 7.66]	3.3e-2	27
15 years	0.01	1.09 [0.37, 3.18]	8.8e-1	10
5 years	0.00	3.99 [1.66, 9.59]	2.0e-3	11
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: E4_CUSHING – Cushing syndrome
GWS hits: 0

Survival analyses between endpoints

↥

Plot

before Cushing syndrome
after Cushing syndrome

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Cushing syndrome

↥