Amyloidosis, other/unspecified

E4_AMYLNAS

amyloidosis: A disorder characterized by the localized or diffuse accumulation of amyloid protein in various anatomic sites. It may be primary, due to clonal plasma cell proliferations; secondary, due to long standing infections, chronic inflammatory disorders, or malignancies; or familial. It may affect the nerves, skin, tongue, joints, heart, liver, spleen, kidneys and adrenal glands.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E85[8-9]

Hospital discharge: ICD-9 2773

Hospital discharge: ICD-8 27699

Cause of death: ICD-10 E85[8-9]

Cause of death: ICD-9 2773

Cause of death: ICD-8 27699

592

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

305

Check minimum number of events None

305

Include endpoints None

305

E4_AMYLNAS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Amyloidosis, other/unspecified based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	299	157	142
Unadjusted prevalence (%)	0.10	0.09	0.11
Mean age at first event (years)	61.39	59.11	63.92

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_AMYLNAS – Amyloidosis, other/unspecified
GWS hits: 6

Survival analyses between endpoints

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Plot

before Amyloidosis, other/unspecified
after Amyloidosis, other/unspecified

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Table

Loading survival analyses table

Drugs most likely to be purchased after Amyloidosis, other/unspecified

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