Myocardial infarction, strict

I9_MI_STRICT

coronary thrombosis: Coagulation of blood in any of the coronary vessels. The presence of a blood clot (thrombus) often leads to myocardial infarction.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I21, I22

Hospital discharge: ICD-9 410

Hospital discharge: ICD-8 410

Hospital discharge: excluded ICD-10 I21.90, I21.97, I22.90, I22.97

Cause of death: ICD-10 I21, I22

Cause of death: ICD-9 410

Cause of death: ICD-8 410

Cause of death: excluded ICD-10 I21.90, I21.97, I22.90, I22.97

20390

Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

18963

Check minimum number of events None

18963

Include endpoints None

18963

I9_MI_STRICT

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF4

Similar endpoints

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List of similar endpoints to Myocardial infarction, strict based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	18339	4822	13517
Unadjusted prevalence (%)	5.94	2.78	10.01
Mean age at first event (years)	65.54	69.03	64.30

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	3.79 [3.33, 4.31]	2.0e-90	6787
15 years	0.01	1.83 [1.63, 2.06]	7.2e-24	2320
5 years	0.00	3.21 [2.91, 3.54]	<1e-100	1374
1 year	0.00	27.58 [24.53, 31.00]	<1e-100	2472

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_MI_STRICT – Myocardial infarction, strict
GWS hits: 21

Survival analyses between endpoints

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Plot

before Myocardial infarction, strict
after Myocardial infarction, strict

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Table

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Drugs most likely to be purchased after Myocardial infarction, strict

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