Major coronary heart disease event

DOID EFO MESH PheWeb

I9_CHD

intermediate coronary syndrome: Precordial pain at rest, which may precede a MYOCARDIAL INFARCTION.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 I20.0, I21, I22

Hospital discharge: ICD-9 410|4110

Hospital discharge: ICD-8 410|4110

Cause of death: ICD-10 I21, I22, I23, I24, I25, I46, R96, R98

Cause of death: ICD-9 41[0-4]|798

Cause of death: ICD-8 41[0-4]|798

Cause of death: excluded ICD-9 7980A

29825

Check pre-conditions, main-only, mode, ICD version

Check only main diagnosis Yes, side diagnoses are not checked

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

26817

Check minimum number of events None

26817

Include endpoints

I9_REVASC

I9_MI

34712

I9_CHD

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Major coronary heart disease event based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	33628	9935	23693
Unadjusted prevalence (%)	10.90	5.73	17.55
Mean age at first event (years)	65.37	67.66	64.41

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.28 [3.88, 4.72]	<1e-100	10987
15 years	0.01	2.17 [1.97, 2.40]	5.9e-56	3872
5 years	0.00	3.40 [3.12, 3.71]	<1e-100	2036
1 year	0.01	34.22 [30.49, 38.41]	<1e-100	4038

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: I9_CHD – Major coronary heart disease event
GWS hits: 38

Survival analyses between endpoints

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Plot

before Major coronary heart disease event
after Major coronary heart disease event

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Table

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Drugs most likely to be purchased after Major coronary heart disease event

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