Metabolic disorder, other/unspecified

E4_METABONAS

metabolic disease: A congenital disorder (due to inherited enzyme abnormality) or acquired (due to failure of a metabolically important organ) disorder resulting from an abnormal metabolic process.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E88.8#, E88.9#

Hospital discharge: ICD-9 277[8-9]

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E88.8#, E88.9#

Cause of death: ICD-9 277[8-9]

Cause of death: ICD-8 $!$

721

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

E4_METABONAS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Metabolic disorder, other/unspecified based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	52	28	24
Unadjusted prevalence (%)	0.02	0.02	0.02
Mean age at first event (years)	44.29	44.58	43.94

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_METABONAS – Metabolic disorder, other/unspecified
GWS hits:

Survival analyses between endpoints

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Plot

before Metabolic disorder, other/unspecified
after Metabolic disorder, other/unspecified

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Table

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Drugs most likely to be purchased after Metabolic disorder, other/unspecified

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