Hypothyroidism, strict autoimmune

PheWeb

E4_HYTHY_AI_STRICT

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not E4_HYTHY_AI_EXCL

312843

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

E4_HYTHYNAS

34498

E4_HYTHY_AI_STRICT

Extra metadata

First used in FinnGen datafreeze DF7

Similar endpoints

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List of similar endpoints to Hypothyroidism, strict autoimmune based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Hypothyroidism, strict autoimmune, 3 medication purchases required

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	33422	26844	6578
Unadjusted prevalence (%)	10.83	15.47	4.87
Mean age at first event (years)	52.13	50.50	58.80

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.27 [1.09, 1.48]	1.9e-3	2178
15 years	0.01	0.89 [0.78, 1.02]	1.0e-1	1096
5 years	0.00	1.67 [1.46, 1.91]	6.1e-14	567
1 year	0.00	1.69 [1.35, 2.13]	5.9e-6	104

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_HYTHY_AI_STRICT – Hypothyroidism, strict autoimmune
GWS hits: 99

Survival analyses between endpoints

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Plot

before Hypothyroidism, strict autoimmune
after Hypothyroidism, strict autoimmune

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Table

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Drugs most likely to be purchased after Hypothyroidism, strict autoimmune

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