Familial hypercholesterolemia, with ichemic heart disease

PheWeb

E4_FH_IHD

No definition available.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

I9_IHD

50277

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

E4_FH

2263

E4_FH_IHD

Extra metadata

Level in the ICD hierarchy C

First used in FinnGen datafreeze DF6v3

Similar endpoints

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List of similar endpoints to Familial hypercholesterolemia, with ichemic heart disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2196	744	1452
Unadjusted prevalence (%)	0.71	0.43	1.08
Mean age at first event (years)	65.91	67.43	65.14

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.02	1.85 [1.18, 2.88]	6.8e-3	460
15 years	0.01	1.07 [0.71, 1.59]	7.5e-1	216
5 years	0.00	2.87 [2.11, 3.90]	2.3e-11	158
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: E4_FH_IHD – Familial hypercholesterolemia, with ichemic heart disease
GWS hits:

Survival analyses between endpoints

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Plot

before Familial hypercholesterolemia, with ichemic heart disease
after Familial hypercholesterolemia, with ichemic heart disease

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Table

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Drugs most likely to be purchased after Familial hypercholesterolemia, with ichemic heart disease

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