Type 1 diabetes without complications

DOID EFO MESH SNOMED PheWeb

E4_DM1NOCOMP

type I diabetes mellitus: A chronic condition characterized by minimal or absent production of insulin by the pancreas.

Endpoint definition

↥

FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E10.9

Hospital discharge: ICD-9 2500B

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E10.9

Cause of death: ICD-9 2500B

Cause of death: ICD-8 $!$

7386

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

7386

Check minimum number of events None

7386

Include endpoints None

7386

E4_DM1NOCOMP

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF3

Parent code in ICD-10 E10

Similar endpoints

↥

List of similar endpoints to Type 1 diabetes without complications based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Type 1 diabetes, strict definition, subgroup 2

Show all endpoint correlations

Summary Statistics

↥

Key figures

	All	Female	Male
Number of individuals	7205	3528	3677
Unadjusted prevalence (%)	2.34	2.03	2.72
Mean age at first event (years)	29.26	27.86	30.61

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.54 [3.38, 6.11]	1.4e-23	727
15 years	0.02	2.89 [2.24, 3.72]	3.1e-16	332
5 years	0.00	4.89 [3.93, 6.09]	1.1e-45	164
1 year	0.00	9.14 [6.78, 12.30]	4.5e-48	65

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

↥

Index endpoint: E4_DM1NOCOMP – Type 1 diabetes without complications
GWS hits: 34

Survival analyses between endpoints

↥

Plot

before Type 1 diabetes without complications
after Type 1 diabetes without complications

Loading survival analyses plot

Table

Loading survival analyses table

Drugs most likely to be purchased after Type 1 diabetes without complications

↥