Diabetic ketoacidosis

DM_KETOACIDOSIS

diabetic ketoacidosis: The metabolic condition resulted from uncontrolled diabetes mellitus, in which the shift of acid-base status of the body toward the acid side because of loss of base or retention of acids other than carbonic acid is accompanied by the accumulation of ketone bodies in body tissues and fluids.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 E10.01, E10.1, E11.01, E11.1, E12.1, E13.1, E14.1

Hospital discharge: ICD-9 2500

Hospital discharge: ICD-8 $!$

Hospital discharge: excluded ICD-10 E12.1

Cause of death: ICD-10 E10.01, E10.1, E11.01, E11.1, E12.1, E13.1, E14.1

Cause of death: ICD-9 2500

Cause of death: ICD-8 $!$

Cause of death: excluded ICD-10 E12.1

8592

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

6869

Check minimum number of events None

6869

Include endpoints None

6869

DM_KETOACIDOSIS

Extra metadata

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Diabetic ketoacidosis based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	6712	3083	3629
Unadjusted prevalence (%)	2.18	1.78	2.69
Mean age at first event (years)	34.80	32.20	37.01

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.00 [2.39, 3.77]	3.9e-21	1526
15 years	0.01	1.89 [1.59, 2.25]	3.9e-13	697
5 years	0.00	2.75 [2.36, 3.20]	6.8e-39	354
1 year	0.00	5.34 [4.32, 6.58]	5.6e-55	145

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: DM_KETOACIDOSIS – Diabetic ketoacidosis
GWS hits: 21

Survival analyses between endpoints

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Plot

before Diabetic ketoacidosis
after Diabetic ketoacidosis

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Table

Loading survival analyses table

Drugs most likely to be purchased after Diabetic ketoacidosis

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