Type 2 diabetes, wide definition

T2D_WIDE

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

not PANCREATITIS

316528

Filter registries

Hospital Discharge: ICD-10 E11

Hospital discharge: ICD-9 250.A

Hospital discharge: ICD-8 $!$

Cause of death: ICD-10 E11

Cause of death: ICD-9 250.A

Cause of death: ICD-8 $!$

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

29923

T2D_WIDE

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 E10-E14

Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Similar endpoints

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List of similar endpoints to Type 2 diabetes, wide definition based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	28960	12125	16835
Unadjusted prevalence (%)	9.39	6.99	12.47
Mean age at first event (years)	62.29	61.52	62.85

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.05	4.10 [3.68, 4.56]	<1e-100	6464
15 years	0.01	2.21 [2.01, 2.44]	2.3e-56	2648
5 years	0.00	3.96 [3.64, 4.32]	<1e-100	1943
1 year	0.00	12.66 [11.29, 14.19]	<1e-100	1356

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: T2D_WIDE – Type 2 diabetes, wide definition
GWS hits: 47

Survival analyses between endpoints

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Plot

before Type 2 diabetes, wide definition
after Type 2 diabetes, wide definition

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Table

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Drugs most likely to be purchased after Type 2 diabetes, wide definition

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