Type 2 diabetes, wide definition

T2D_WIDE

type II diabetes mellitus: A type of diabetes mellitus that is characterized by insulin resistance or desensitization and increased blood glucose levels. This is a chronic disease that can develop gradually over the life of a patient and can be linked to both environmental factors and heredity.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions

not PANCREATITIS

316528

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Filter registries

Hospital Discharge: ICD-10 E11
Hospital discharge: ICD-9 250.A
Hospital discharge: ICD-8 $!$
Cause of death: ICD-10 E11
Cause of death: ICD-9 250.A
Cause of death: ICD-8 $!$

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

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Check minimum number of events None

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Include endpoints None

29923

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T2D_WIDE

Extra metadata

First used in FinnGen datafreeze DF2
Parent code in ICD-10 E10-E14
Name in latin Diabetes (mellitus) [obesus/non obesus] adultorum

Summary Statistics

Key figures

All Female Male
Number of individuals 28960 12125 16835
Unadjusted prevalence (%) 9.39 6.99 12.47
Mean age at first event (years) 62.29 61.52 62.85

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.05 4.10 [3.68, 4.56] <1e-100 6464
15 years 0.01 2.21 [2.01, 2.44] 2.3e-56 2648
5 years 0.00 3.96 [3.64, 4.32] <1e-100 1943
1 year 0.00 12.66 [11.29, 14.19] <1e-100 1356

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: T2D_WIDE – Type 2 diabetes, wide definition
GWS hits: 47

Survival analyses between endpoints

Plot

before Type 2 diabetes, wide definition
after Type 2 diabetes, wide definition

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Drugs most likely to be purchased after Type 2 diabetes, wide definition