Parkinson's disease, strict definition

PDSTRICT

secondary Parkinson disease: Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G20

Hospital discharge: ICD-9 3320A

Hospital discharge: ICD-8 34200

Cause of death: ICD-10 G20

Cause of death: ICD-9 3320A

Cause of death: ICD-8 34200

KELA reimbursements: KELA codes 110

KELA reimbursements: ICD-10 G20, G20+F02.39

3075

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

2925

Check minimum number of events None

2925

Include endpoints None

2925

PDSTRICT

Extra metadata

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G20-G26

Name in latin Morbus Parkinson

Similar endpoints

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List of similar endpoints to Parkinson's disease, strict definition based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2844	1164	1680
Unadjusted prevalence (%)	0.92	0.67	1.24
Mean age at first event (years)	68.19	67.32	68.79

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.40 [3.44, 5.64]	6.2e-32	772
15 years	0.02	2.36 [1.89, 2.93]	1.7e-14	377
5 years	0.00	3.80 [3.14, 4.59]	1.1e-42	278
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: PDSTRICT – Parkinson's disease, strict definition
GWS hits: 2

Survival analyses between endpoints

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Plot

before Parkinson's disease, strict definition
after Parkinson's disease, strict definition

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Table

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Drugs most likely to be purchased after Parkinson's disease, strict definition

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