Parkinson's disease


Parkinson's disease: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None


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Check conditions None


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Filter registries

Hospital Discharge: ICD-10 G20
Hospital discharge: ICD-9 3320A
Hospital discharge: ICD-8 34200
Cause of death: ICD-10 G20
Cause of death: ICD-9 3320A
Cause of death: ICD-8 34200
KELA reimbursements: KELA codes 110


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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9


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Check minimum number of events None


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Include endpoints None


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Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 G20-G26
Name in latin Morbus Parkinson

Summary Statistics

Key figures

All Female Male
Number of individuals 2989 1221 1768
Unadjusted prevalence (%) 0.97 0.70 1.31
Mean age at first event (years) 66.84 65.93 67.46


Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.73 [3.98, 5.62] 4.0e-70 800
15 years 0.02 2.55 [2.15, 3.02] 3.0e-27 400
5 years - - - -
1 year - - - -

Age distribution of first events

Year distribution of first events

Cumulative Incidence


Index endpoint: G6_PARKINSON – Parkinson's disease
GWS hits: 2

Survival analyses between endpoints


before Parkinson's disease
after Parkinson's disease

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Drugs most likely to be purchased after Parkinson's disease