Parkinson's disease

G6_PARKINSON

Parkinson's disease: A progressive degenerative disorder of the central nervous system characterized by loss of dopamine producing neurons in the substantia nigra and the presence of Lewy bodies in the substantia nigra and locus coeruleus. Signs and symptoms include tremor which is most pronounced during rest, muscle rigidity, slowing of the voluntary movements, a tendency to fall back, and a mask-like facial expression.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 G20

Hospital discharge: ICD-9 3320A

Hospital discharge: ICD-8 34200

Cause of death: ICD-10 G20

Cause of death: ICD-9 3320A

Cause of death: ICD-8 34200

KELA reimbursements: KELA codes 110

3075

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

3075

Check minimum number of events None

3075

Include endpoints None

3075

G6_PARKINSON

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 G20-G26

Name in latin Morbus Parkinson

Similar endpoints

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List of similar endpoints to Parkinson's disease based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	2989	1221	1768
Unadjusted prevalence (%)	0.97	0.70	1.31
Mean age at first event (years)	66.84	65.93	67.46

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.06	4.73 [3.98, 5.62]	4.0e-70	800
15 years	0.02	2.55 [2.15, 3.02]	3.0e-27	400
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: G6_PARKINSON – Parkinson's disease
GWS hits: 2

Survival analyses between endpoints

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Plot

before Parkinson's disease
after Parkinson's disease

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Table

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Drugs most likely to be purchased after Parkinson's disease

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