Other specified/unspecified systemic involvement of connective tissue

M13_CONNECTNAS

connective tissue disease: A disorder characterized by abnormalities in one or more of the elements of the connective tissues, typically associated with genetic defects.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 M35.8, M35.9

Hospital discharge: ICD-9 710[8-9]

Hospital discharge: ICD-8 7349[1-9]

Cause of death: ICD-10 M35.8, M35.9

Cause of death: ICD-9 710[8-9]

Cause of death: ICD-8 7349[1-9]

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

1369

M13_CONNECTNAS

Extra metadata

Level in the ICD hierarchy 4

First used in FinnGen datafreeze DF2

Similar endpoints

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List of similar endpoints to Other specified/unspecified systemic involvement of connective tissue based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1329	1047	282
Unadjusted prevalence (%)	0.43	0.60	0.21
Mean age at first event (years)	49.33	47.99	54.30

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.04	3.23 [1.96, 5.32]	4.2e-6	108
15 years	0.01	1.96 [1.22, 3.17]	5.8e-3	46
5 years	0.00	3.64 [2.28, 5.79]	5.6e-8	28
1 year	0.00	8.10 [4.71, 13.90]	3.5e-14	14

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: M13_CONNECTNAS – Other specified/unspecified systemic involvement of connective tissue
GWS hits: 1

Survival analyses between endpoints

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Plot

before Other specified/unspecified systemic involvement of connective tissue
after Other specified/unspecified systemic involvement of connective tissue

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Table

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Drugs most likely to be purchased after Other specified/unspecified systemic involvement of connective tissue

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