Mental retardation

KRA_PSY_MENTALRET

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 F70-F79
Hospital discharge: ICD-9 31[7-9]
Hospital discharge: ICD-8 31[1-5]
Cause of death: ICD-10 F70-F79
Cause of death: ICD-9 31[7-9]
Cause of death: ICD-8 31[1-5]

1461

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1021

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Check minimum number of events None

1021

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Include endpoints None

1021

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KRA_PSY_MENTALRET

Extra metadata

First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 957 470 487
Unadjusted prevalence (%) 0.31 0.27 0.36
Mean age at first event (years) 26.87 26.85 26.90

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.08 6.46 [3.44, 12.15] 6.7e-9 87
15 years 0.02 3.78 [2.04, 6.99] 2.3e-5 37
5 years 0.01 5.98 [2.65, 13.45] 1.6e-5 18
1 year 0.00 20.39 [8.92, 46.59] 8.8e-13 12

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: KRA_PSY_MENTALRET – Mental retardation
GWS hits: 0

Survival analyses between endpoints

Plot

before Mental retardation
after Mental retardation

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Drugs most likely to be purchased after Mental retardation