Mental retardation

F5_MENTRET

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

FinnGen phenotype data

321302 individuals

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Apply sex-specific rule None

321302

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Check conditions None

321302

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Filter registries

Hospital Discharge: ICD-10 F70-F79
Cause of death: ICD-10 F70-F79

821

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Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10 ; C.O.D: 10

821

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Check minimum number of events None

821

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F5_MENTRET

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Summary Statistics

Key figures

All Female Male
Number of individuals 1008 493 515
Unadjusted prevalence (%) 0.33 0.28 0.38
Mean age at first event (years) 26.00 26.25 25.75

Mortality

Follow-up Absolute risk HR [95% CI] p N
1998–2019 0.06 4.39 [2.20, 8.77] 2.7e-5 98
15 years 0.02 2.68 [1.38, 5.17] 3.4e-3 44
5 years 0.00 3.89 [1.83, 8.28] 4.2e-4 17
1 year 0.00 12.27 [5.37, 28.05] 2.8e-9 10

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

Index endpoint: F5_MENTRET – Mental retardation
GWS hits: 1

Survival analyses between endpoints

Plot

before Mental retardation
after Mental retardation

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Drugs most likely to be purchased after Mental retardation