Profound mental retardation

F5_PRORET

mental retardation: ['Subnormal intellectual functioning which originates during the developmental period. This has multiple potential etiologies, including genetic defects and perinatal insults. Intelligence quotient (IQ) scores are commonly used to determine whether an individual is mentally retarded. IQ scores between 70 and 79 are in the borderline mentally retarded range. Scores below 67 are in the retarded range. (Joynt, Clinical Neurology, 1992, Ch55, p28)']

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 F73

Hospital discharge: ICD-9 3182

Hospital discharge: ICD-8 314

Cause of death: ICD-10 F73

Cause of death: ICD-9 3182

Cause of death: ICD-8 314

121

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

Check minimum number of events None

Include endpoints None

F5_PRORET

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 F70-F79

Name in latin Retardatio mentalis profunda

Similar endpoints

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List of similar endpoints to Profound mental retardation based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	27	16	11
Unadjusted prevalence (%)	0.01	0.01	0.01
Mean age at first event (years)	29.66	34.44	22.72

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: F5_PRORET – Profound mental retardation
GWS hits:

Survival analyses between endpoints

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Plot

before Profound mental retardation
after Profound mental retardation

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Table

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Drugs most likely to be purchased after Profound mental retardation

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