Cholangitis (primary sclerosing, PSC)

K11_CHOLANGI

sclerosing cholangitis: A chronic, autoimmune inflammatory liver disorder characterized by narrowing and scarring of the lumen of the bile ducts. It is often seen in patients with ulcerative colitis. Signs and symptoms include jaundice, fatigue, and malabsorption. It may lead to cirrhosis and liver failure.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions None

321302

Filter registries

Hospital Discharge: ICD-10 K83.0

Hospital discharge: ICD-9 5761

Hospital discharge: ICD-8 5750[4-5]

Cause of death: ICD-10 K83.0

Cause of death: ICD-9 5761

Cause of death: ICD-8 5750[4-5]

1269

Check pre-conditions, main-only, mode, ICD version

Look only at ICD versions H.D: 10, 8, 9 ; C.O.D: 10, 8, 9

1269

Check minimum number of events None

1269

Include endpoints None

1269

K11_CHOLANGI

Extra metadata

Level in the ICD hierarchy 3

First used in FinnGen datafreeze DF2

Parent code in ICD-10 K83

Name in latin Cholangitis

Similar endpoints

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List of similar endpoints to Cholangitis (primary sclerosing, PSC) based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

Show all endpoint correlations

Summary Statistics

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Key figures

	All	Female	Male
Number of individuals	1231	605	626
Unadjusted prevalence (%)	0.40	0.35	0.46
Mean age at first event (years)	56.79	54.61	58.89

Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	0.08	6.80 [4.89, 9.47]	6.2e-30	241
15 years	0.01	2.06 [1.46, 2.90]	3.4e-5	64
5 years	0.00	3.70 [2.30, 5.94]	6.4e-8	60
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_CHOLANGI – Cholangitis (primary sclerosing, PSC)
GWS hits: 0

Survival analyses between endpoints

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Plot

before Cholangitis (primary sclerosing, PSC)
after Cholangitis (primary sclerosing, PSC)

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Table

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Drugs most likely to be purchased after Cholangitis (primary sclerosing, PSC)

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