Ulcerative colitis (strict) with PSC

K11_UC_STRICT_PSC

ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.

Endpoint definition

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FinnGen phenotype data

321302 individuals

Apply sex-specific rule None

321302

Check conditions

K11_CHOLANGI_STRICT

and K11_UC_STRICT

169

Filter registries None

Check pre-conditions, main-only, mode, ICD version None

Check minimum number of events None

Include endpoints

K11_CHOLANGI_STRICT

K11_UC_STRICT

169

K11_UC_STRICT_PSC

Extra metadata

First used in FinnGen datafreeze DF4

Similar endpoints

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List of similar endpoints to Ulcerative colitis (strict) with PSC based on the number of shared cases.

Broader endpoints:

Narrower endpoints:

None

Show all endpoint correlations

Summary Statistics

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Key figures

All

Female

Male

Number of individuals

167

Unadjusted prevalence (%)

0.05

0.04

0.07

Mean age at first event (years)

29.82

29.90

29.75

?

Follow-up

Amount of time to look for the endpoint since entering the study. This is either either 1, 5, 15 years or the full study time from 1998 to 2019.

Absolute risk

Estimates the probability of dying from the current endpoint. Check the Documentation page for Mortality: absolute risk to get more details.

Hazard Ratio (HR) and 95% Confidence Interval (CI)

Measures how much the risk of dying increases (HR > 1) or decreases (HR < 1).

Number of individuals (N)

Number of individuals having the current endpoint and died during the follow-up time.
Mortality

Follow-up	Absolute risk	HR [95% CI]	p	N
1998–2019	-	-	-	-
15 years	-	-	-	-
5 years	-	-	-	-
1 year	-	-	-	-

Age distribution of first events

Year distribution of first events

Cumulative Incidence

Correlations

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Index endpoint: K11_UC_STRICT_PSC – Ulcerative colitis (strict) with PSC
GWS hits: 0

Survival analyses between endpoints

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Plot

before Ulcerative colitis (strict) with PSC
after Ulcerative colitis (strict) with PSC

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Table

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Drugs most likely to be purchased after Ulcerative colitis (strict) with PSC

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